期刊
FEBS LETTERS
卷 586, 期 9, 页码 1336-1343出版社
WILEY
DOI: 10.1016/j.febslet.2012.03.045
关键词
Tapasin; MHC-I; Peptide; Stability; Vaccine
资金
- Novo Nordisk foundation
- Lundbeck foundation
- Swedish Medical Research Council [2006-6500]
- Crafoord foundation
- Royal Physiographic Society in Lund
- Thelma Zoegas foundation
- Magnus Bergvalls foundation
- Osterlunds foundation
- Groschinskys foundation
- Greta & Johan Kocks foundation
Only a small fraction of the peptides generated inside the cell end up being presented by HLA-I on the cell surface. High stability of peptide-HLA-I complexes and a low HLA-I tapasin-facilitation have been proposed to predict immunogenicity. We here set out to investigate if these parameters correlated and defined immunogenic peptides. Both peptide-HLA-B*08:01 and peptide-HLA-A*02:01 complexes showed small differences in tapasin-facilitation and larger differences in stability. This suggests that the stability of immunogenic peptide-HLA-I complexes vary above an HLA-I allomorph dependent lower limit (e. g. > 2 h for HLA-A*02:01), immunogenicity predicted by tapasin-facilitation may be defined by an equally allomorph unique upper value (e. g. tapasin-facilitation <1.5 for HLA-A*02:01), and variation above the stability-threshold does not directly reflect a variation in tapasin-facilitation. (C) 2012 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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