期刊
FEBS LETTERS
卷 586, 期 10, 页码 1504-1509出版社
WILEY
DOI: 10.1016/j.febslet.2012.04.007
关键词
Potassium channel; Ovarian cancer; Platelet-derived growth factor; Glybenclamide; Trafficking; Tumor invasion
资金
- Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan
- Grants-in-Aid for Scientific Research [20113008] Funding Source: KAKEN
It has been demonstrated that potassium channels (K+ channels) play significant roles in some malignant phenotypes. Here, we provide the first evidence that treatment with glybenclamide, an ATP-sensitive K+ channel blocker, inhibited cell migration in an ovarian clear cell carcinoma cell line, ES-2. Treatment with glybenclamide or knockdown by siRNA targeted against K+ channel sub-units demonstrated the suppression of ovarian cancer cell invasion, which occurred via inhibition of PDGF-AA secretion. Therefore, our findings suggest that K+ channel blockers may be useful chemotherapeutic drugs for blocking the invasiveness of ovarian cancers. (c) 2012 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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