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ALLERGY (2011)
Identification of PARP-1 as one of the transcription factors binding to the repressor element in the promoter region of COX-2
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ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2011)
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Loss of Tankyrase-Mediated Destruction of 3BP2 Is the Underlying Pathogenic Mechanism of Cherubism
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CELL METABOLISM (2011)
Poly(ADP-ribose) polymerase-1 is a key mediator of cisplatin-induced kidney inflammation and injury
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PARP-14 Functions as a Transcriptional Switch for Stat6-dependent Gene Activation
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JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
The potential for poly (ADP-ribose) polymerase inhibitors in cancer therapy
M. Javle et al.
Therapeutic Advances in Medical Oncology (2011)
Poly(ADP-ribose) polymerase (PARP) inhibition counteracts multiple manifestations of kidney disease in long-term streptozotocin-diabetic rat model
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BIOCHEMICAL PHARMACOLOGY (2010)
Mechanical stretch enhances NF-κB-dependent gene expression and poly(ADP-ribose) synthesis in synovial cells
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JOURNAL OF BIOCHEMISTRY (2010)
Increased Foxp3+ Regulatory T Cells in Poly(ADP-Ribose) Polymerase-1 Deficiency
Francesca Nasta et al.
JOURNAL OF IMMUNOLOGY (2010)
Genetic Ablation of PARP-1 Protects Against Oxazolone-Induced Contact Hypersensitivity by Modulating Oxidative Stress
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JOURNAL OF INVESTIGATIVE DERMATOLOGY (2010)
A Cytoplasmic ATM-TRAF6-cIAP1 Module Links Nuclear DNA Damage Signaling to Ubiquitin-Mediated NF-κB Activation
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MOLECULAR CELL (2010)
Physiological consequences of programmed necrosis, an alternative form of cell demise
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MOLECULES AND CELLS (2010)
Loss of poly(ADP-ribose) polymerase-2 leads to rapid development of spontaneous T-cell lymphomas in p53-deficient mice
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ONCOGENE (2010)
Honokiol protects rats against eccentric exercise-induced skeletal muscle damage by inhibiting NF-κB induced oxidative stress and inflammation
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EUROPEAN JOURNAL OF PHARMACOLOGY (2009)
Dual role of poly(ADP-ribose) glycohydrolase in the regulation of cell death in oxidatively stressed A549 cells
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FASEB JOURNAL (2009)
PARP inhibitors: New partners in the therapy of cancer and inflammatory diseases
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FREE RADICAL BIOLOGY AND MEDICINE (2009)
Poly(ADP-ribose) polymerase-1 (Parp-1)-deficient mice demonstrate abnormal antibody responses
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IMMUNOLOGY (2009)
Poly(ADP-Ribose) Polymerase Mediates Inflammation in a Mouse Model of Contact Hypersensitivity
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JOURNAL OF INVESTIGATIVE DERMATOLOGY (2009)
Thieno[2,3-c]Isoquinolin-5-one, a Potent Poly(ADP-Ribose) Polymerase Inhibitor, Promotes Atherosclerotic Plaque Regression in High-Fat Diet-Fed Apolipoprotein E-Deficient Mice: Effects on Inflammatory Markers and Lipid Content
Chetan P. Hans et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2009)
A randomized, placebo-controlled trial to evaluate the tolerability, safety, pharmacokinetics, and pharmacodynamics of a potent inhibitor of poly(ADP-ribose) polymerase (INO-1001) in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention: results of the TIMI 37 trial
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JOURNAL OF THROMBOSIS AND THROMBOLYSIS (2009)
A Nuclear Poly(ADP-Ribose)-Dependent Signalosome Confers DNA Damage-Induced IκB Kinase Activation
Michael Stilmann et al.
MOLECULAR CELL (2009)
Inhibition of Poly(ADP-Ribose) Polymerase in Tumors from BRCA Mutation Carriers.
Peter C. Fong et al.
NEW ENGLAND JOURNAL OF MEDICINE (2009)
Role of the peroxynitrite-poly(ADP-ribose) polymerase pathway in human disease
Pal Pacher et al.
AMERICAN JOURNAL OF PATHOLOGY (2008)
Poly (ADP-ribose) polymerases (PARPs) 1-3 regulate astrocyte activation
Nirmal K. Phulwani et al.
JOURNAL OF NEUROCHEMISTRY (2008)
Regulation of transcription factor NFAT by ADP-ribosylation
Opeyemi A. Olabisi et al.
MOLECULAR AND CELLULAR BIOLOGY (2008)
Regulation of NFAT by poly (ADP-ribose) polymerase activity in T cells
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MOLECULAR IMMUNOLOGY (2008)
Inflammatory and transcriptional roles of poly (ADP-ribose) polymerase in ventilator-induced lung injury
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CRITICAL CARE (2008)
Peroxisome proliferator-activated receptor (PPAR)-2 controls adipocyte differentiation and adipose tissue function through the regulation of the activity of the retinoid x receptor/PPARγ heterodimer
Peter Bai et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Poly-(ADP-ribose) polymerase-1 (Parp-1) binds in a sequence-specific manner at the Bcl-6 locus and contributes to the regulation of Bcl-6 transcription
H. E. Ambrose et al.
ONCOGENE (2007)
Peroxynitrite: biochemistry, pathophysiology and development of therapeutics
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NATURE REVIEWS DRUG DISCOVERY (2007)
Retrodifferentiation and rejuvenation of senescent monocytic cells requires PARP-1
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EXPERIMENTAL GERONTOLOGY (2007)
Protein tyrosine nitration and poly(ADP-ribose) polymerase activation in N-methyl-N-nitro-N-nitrosoguanidine-treated thymocytes:: Implication for cytotoxicity
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TOXICOLOGY LETTERS (2007)
Poly(ADP-ribose) polymerase inhibition reduces atherosclerotic plaque size and promotes factors of plaque stability in apolipoprotein E-deficient mice -: Effects on macrophage recruitment, nuclear factor-κB nuclear translocation, and foam cell death
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CIRCULATION (2007)
Prolonged poly(ADP-ribose) polymerase-1 activity regulates JP-8-induced sustained cytokine expression in alveolar macrophages
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FREE RADICAL BIOLOGY AND MEDICINE (2007)
Expression of adhesion molecular proteins in the cochlear lateral wall of normal and PARP-1 mutant mice
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HEARING RESEARCH (2007)
Nitric oxide and peroxynitrite in health and disease
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PHYSIOLOGICAL REVIEWS (2007)
The dual personalities of matrix metalloproteinases in inflammation
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FRONTIERS IN BIOSCIENCE (2007)
Poly(ADP-ribose) polymerase inhibitors ameliorate nephropathy of type 2 diabetic Leprdb/db mice
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DIABETES (2006)
PARP-2 deficiency affects the survival of CD4+CD8+ double-positive thymocytes
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EMBO JOURNAL (2006)
Anti-inflammatory effects of PJ34, a poly(ADP-ribose) polymerase inhibitor, in transient focal cerebral ischemia in mice
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BRITISH JOURNAL OF PHARMACOLOGY (2006)
Poly(ADP-ribose) polymerase (PARP) polymorphisms associated with nephritis and arthritis in systemic lupus erythematosus
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Gender differences in the endotoxin-induced inflammatory and vascular responses:: Potential role of poly(ADP-ribose) polymerase activation
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Effect of 3-aminobenzamide, PARP inhibitor, on matrix metalloproteinase-9 level in plasma and brain of ischemic stroke model
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TOXICOLOGY (2005)
Inhibition of poly(ADP-ribose) polymerase attenuates the severity of acute pancreatitis and associated lung injury
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IL-6 induces regionally selective spinal cord injury in patients with the neuroinflammatory disorder transverse myelitis
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JOURNAL OF CLINICAL INVESTIGATION (2005)
Defective transcription factor activation for proinflammatory gene expression in poly(ADP-ribose) polymerase 1-deficient glia
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Poly (ADP) ribose synthetase inhibition reduces obliterative airway disease in rat tracheal allografts
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JOURNAL OF HEART AND LUNG TRANSPLANTATION (2004)
Restoration of the endothelial function in the aortic rings of apolipoprotein E deficient mice by pharmacological inhibition of the nuclear enzyme poly(ADP-ribose) polymerase
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LIFE SCIENCES (2004)
Activator protein-1 signalling pathway and apoptosis are modulated by poly(ADP-ribose) polymerase-1 in experimental colitis
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IMMUNOLOGY (2004)
Treatment with a novel poly (ADP-ribose) glycohydrolase inhibitor reduces development of septic shock-like syndrome induced by zymosan in mice
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CRITICAL CARE MEDICINE (2004)
Inhibition of poly(ADP-ribose) glycohydrolase by gallotannin selectively up-regulates expression of proinflammatory genes
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MOLECULAR PHARMACOLOGY (2004)
NAD+ repletion prevents PARP-1-induced glycolytic blockade and cell death in cultured mouse astrocytes
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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2003)
Systemic poly(ADP-ribose) polymerase-1 activation, chronic inflammation, and oxidative stress in COPD patients
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FREE RADICAL BIOLOGY AND MEDICINE (2003)
Gene knockout or pharmacological inhibition of Poly(ADP-Ribose) polymerase-1 prevents lung inflammation in a murine model of asthma
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AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2003)
A poly(ADP-ribose) polymerase haplotype spanning the promoter region confers susceptibility to rheumatoid arthritis
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ARTHRITIS AND RHEUMATISM (2003)
Antisense oligonucleotides to poly(ADP-ribose) polymerase-2 ameliorate colitis in interleukin-10-deficient mice
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JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2002)
Active caspase-8 translocates into the nucleus of apoptotic cells to inactivate poly(ADP-ribose) polymerase-2
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JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Pharmacologic inhibition of poly(adenosine diphosphate-ribose) polymerase novel therapeutic approach rase may represent a in chronic heart failure
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JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2002)
The therapeutic potential of poly(ADP-ribose) polymerase inhibitors
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Elevated levels of oxidative DNA damage and DNA repair enzymes in human atherosclerotic plaques
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CIRCULATION (2002)
Poly(ADP-ribose) polymerase-2 (PARP-2) is required for efficient base excision DNA repair in association with PARP-1 and XRCC1
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JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Nitric oxide-peroxynitrite-poly(ADP-ribose) polymerase pathway in the skin
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CRITICAL CARE MEDICINE (2002)
Resistance to acute septic peritonitis in poly(ADP-ribose) polymerase-1-deficient mice
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SHOCK (2002)
Poly(ADP-ribose) polymerase-1 dependence of stress-induced transcription factors and associated gene expression in glia
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Meningitis-associated central nervous system complications are mediated by the activation of poly(ADP-ribose) polymerase
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JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2002)
Reduction of acute photodamage in skin by topical application of a novel PARP inhibitor
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BIOCHEMICAL PHARMACOLOGY (2002)
Pyrrolidine dithiocarbamate attenuates the development of acute and chronic inflammation
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BRITISH JOURNAL OF PHARMACOLOGY (2002)
Partial protection by poly(ADP-ribose) polymerase inhibitors from nitroxyl-induced cytotoxicity in thymocytes
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FREE RADICAL BIOLOGY AND MEDICINE (2001)
The enzymatic and DNA binding activity of PARP-1 are not required for NF-κB coactivator function
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JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Anti-inflammatory effects of a novel, potent inhibitor of poly (ADP-ribose) polymerase
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INFLAMMATION RESEARCH (2001)
Rapid reversal of the diabetic endothelial dysfunction by pharmacological inhibition of poly(ADP-ribose) polymerase
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CIRCULATION RESEARCH (2001)
Role of poly(ADP-ribose) synthetase activation in the development of experimental allergic encephalomyelitis
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JOURNAL OF NEUROIMMUNOLOGY (2001)
Peroxynitrite production, DNA breakage, and poly(ADP-ribose) polymerase activation in a mouse model of oxazolone-induced contact hypersensitivity
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JOURNAL OF INVESTIGATIVE DERMATOLOGY (2001)
Diabetic endothelial dysfunction: the role of poly(ADP-ribose) polymerase activation
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NATURE MEDICINE (2001)
Protection against hemorrhagic shock in mice genetically deficient in poly(ADP-ribose)polymerase
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
Role of poly-(ADP-ribose) synthetase in lipopolysaccharide-induced vascular failure and acute lung injury in pigs
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