期刊
FEBS LETTERS
卷 586, 期 21, 页码 3771-3777出版社
WILEY
DOI: 10.1016/j.febslet.2012.09.026
关键词
Inflammation; Allergy; Oxidative stress; Nitrosative stress; Chemokine; Adhesion molecule; Gene expression
资金
- Bolyai fellowship
- National Innovation Office [TeT_09-2010-0023, TAMOP-4.2.1./B-09/KONV-2010-0007, TAMOP-4.2.2. A-11/1/KONV-2012-0025, TAMOP-4.2.2/B-10/1-2010-0024]
- OTKA [CNK80709, K82009, K75864, PD83473, K105872]
- University of Debrecen, Medical and Health Science Center [Mec-8/2011]
PARP enzymes influence the immune system at several key points and thus modulate inflammatory diseases. PARP enzymes affect immune cell maturation and differentiation and regulate the expression of inflammatory mediators such as cytokines, chemokines, inducible nitric oxide synthase and adhesion molecules. Moreover, PARP enzymes are key regulators of cell death during inflammation-related oxidative and nitrosative stress. Here we provide an overview of the different inflammatory diseases regulated by PARP enzymes. (C) 2012 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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