期刊
FEBS LETTERS
卷 585, 期 11, 页码 1537-1542出版社
WILEY
DOI: 10.1016/j.febslet.2011.03.015
关键词
Calorie restriction; Aging; Chronic disease; Prevention
资金
- National Center for Research Resources [UL1 RR024992]
- National Institute of Diabetes and Digestive and Kidney Diseases [P30DK056341]
- Istituto Superiore di Sanita/National Institutes of Health, Ministero della Salute, the Longer Life Foundation (an RGA/Washington University)
- Bakewell Foundation
- Scott and Annie Appleby Charitable Trust
Life expectancy in the world has increased dramatically during the last century; the number of older adults is expected to rise while the number of youths will decline in the near future. This demographic shift has considerable public health and economic implications since aging is associated with the development of serious chronic diseases. Calorie restriction (CR) is the most effective nutritional intervention for slowing aging and preventing chronic disease in rodents. In non-human and human primates, CR with adequate nutrition protects against abdominal obesity, diabetes, hypertension and cardiovascular diseases. Cancer morbidity and mortality are also diminished in CR monkeys, and data obtained from individuals practicing long-term CR show a reduction of metabolic and hormonal factors associated with increased cancer risk. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据