期刊
FEBS LETTERS
卷 585, 期 9, 页码 1322-1330出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2011.03.067
关键词
Cell migration; Cell invasion; Hepatocellular carcinoma; MicroRNA-142-3p; RAC1; Target gene; MiRNA
资金
- National Natural Science Foundation of China [30873017, 91029714, 31071191]
- Natural Science Foundation of Tianjin [08JCZDJC23300, 09JCZDJC17500]
RAC1 regulates a diverse array of cellular events including migration and invasion. MicroRNAs (miRNAs) have a key role in the regulation of gene expression. In this study, we demonstrated that microRNA-142-3p (miR-142-3p) acted as a negative regulator of human RAC1. Overexpression of miR142-3p decreased RAC1 mRNA and protein levels. Moreover, the overexpression of miR-142-3p suppressed, while blocking of miR-142-3p increased colony formation, migration and invasion in hepatocellular carcinoma (HCC) cell lines (QGY-7703 and SMMC-7721). RAC1 overexpression without the 3'untranslated region abolished the effect of miR-142-3p in the QGY-7703 and SMMC-7721 cells. These results demonstrated that miR-142-3p directly and negatively regulates RAC1 in HCC cells, which highlights the importance of miRNAs in tumorigenesis. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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