期刊
FEBS LETTERS
卷 585, 期 23, 页码 3660-3666出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2011.04.028
关键词
Toll-like receptor; Rheumatologic disease; Autoimmunity; Innate immunity
In the last decade Toll-like receptor (TLR) research has led to new insights in the pathogenesis of many rheumatic diseases. In autoimmune diseases like systemic lupus erythematosus, rheumatoid arthritis and systemic sclerosis TLR signaling is likely to be involved in tolerance breakthrough and chronic inflammation via combined Fc gamma receptors and TLR recognition of immune complexes. Furthermore, inflammatory diseases like psoriatic arthritis and gout also show more and more evidence for TLR involvement. In this review we will discuss the involvement of TLR signaling in several rheumatic diseases and stress their similarities and differences based on recent findings. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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