期刊
FEBS LETTERS
卷 585, 期 18, 页码 2920-2928出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2011.08.008
关键词
PCNA; Ubiquitin; SUMO; DNA replication; DNA repair
资金
- National Science Foundation
- Purdue University Center for Cancer Research
- Indiana Clinical and Translational Sciences Institute
- Div Of Molecular and Cellular Bioscience
- Direct For Biological Sciences [1121240] Funding Source: National Science Foundation
A vast array of proteins is recruited to the replication fork in a dynamic and coordinated manner through physical interactions with Proliferating Cell Nuclear Antigen, PCNA. How this complex exchange of PCNA binding partners is choreographed to ensure proper replication origin licensing, DNA synthesis during normal replication or repair of DNA damage, chromatin assembly, DNA methylation, histone modification, and sister chromatid cohesion is only beginning to be appreciated. In this review, several roles of ubiquitin-related modifications in the recruitment and turnover of PCNA-interacting proteins at the replication fork are considered. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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