期刊
FEBS LETTERS
卷 585, 期 18, 页码 2907-2913出版社
WILEY
DOI: 10.1016/j.febslet.2011.04.067
关键词
SMC proteins; Cohesin; SUMO ligase; DNA double-strand break repair; Homologous recombination
资金
- Health Research Board [RP/2008/67]
- Science Foundation Ireland [08/IN.1/B1029]
- Health Research Board (HRB) [RP-2008-67] Funding Source: Health Research Board (HRB)
- Science Foundation Ireland (SFI) [08/IN.1/B1029] Funding Source: Science Foundation Ireland (SFI)
There exist three highly-conserved structural maintenance of chromosomes (Smc) complexes that ensure genome stability during eukaryotic cell division. There are the well-characterized cohesin and condensin complexes and the third Smc complex, Smc5/6. Nse2/Mms21, a SUMO ligase, is a component of the Smc5/6 complex and recent data have indicated that Nse1 may function as a ubiquitin ligase. Smc5/6 regulates sister chromatid cohesion, homologous recombination and chromatin structure and conformation. This review examines the functions of Smc5/6 in DNA repair and the maintenance of genomic integrity and explores the roles of the associated SUMO and ubiquitin ligases. Recent findings have indicated that Smc5/6 may play a topological role in chromosome dynamics, which may help understand the complexity of its activities. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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