期刊
FEBS LETTERS
卷 585, 期 11, 页码 1663-1672出版社
WILEY
DOI: 10.1016/j.febslet.2011.05.014
关键词
ILK; PINCH; Parvin; Rac; Mammary epithelial; Differentiation
资金
- Wellcome Trust
Differentiation into tissue-specific cell types occurs in response to numerous external signals. Integrins impart signals from the extracellular matrix microenvironment that are required for cell differentiation. However, the precise cytoplasmic transducers of these signals are yet to be understood properly. In lactating mammary epithelial cells, integrin-linked kinase has been identified as an indispensable integrin-signalling adaptor that enables the activation of Rac1, which is necessary for prolactin-induced milk protein expression. Here we use examples from various tissues to summarise possible mechanisms by which ILK and its binding partners PINCH and Parvin (ILK-PINCH-Parvin complex) could be required for Rac activation and mammary epithelial differentiation. (C) 2011 Published by Elsevier B. V. on behalf of the Federation of European Biochemical Societies.
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