期刊
FEBS LETTERS
卷 585, 期 5, 页码 723-729出版社
WILEY
DOI: 10.1016/j.febslet.2011.01.041
关键词
EPEC; IQGAP1; Microbial pathogenesis; Salmonella
资金
- Canadian Institutes of Health Research
- National Institutes of Health
Microbial pathogens cause widespread morbidity and mortality. Central to the pathogens' virulence is manipulation of the host cell's cytoskeleton, which facilitates microbial invasion, multiplication, and avoidance of the innate immune response. IQGAP1 is a ubiquitously expressed scaffold protein that integrates diverse signaling cascades. Research has shown that IQGAP1 binds to and modulates the activity of multiple proteins that participate in bacterial invasion. Here, we review data that support a role for IQGAP1 in infectious disease via its ability to regulate the actin cytoskeleton. In addition, we explore other mechanisms by which IQGAP1 may be exploited by microbial pathogens. Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.
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