期刊
FEBS LETTERS
卷 585, 期 23, 页码 3781-3788出版社
WILEY
DOI: 10.1016/j.febslet.2011.03.047
关键词
Astrocyte; Neuroinflammation; Multiple sclerosis; Blood-brain barrier; Extracellular matrix
资金
- Serbian Ministry of Science and Technological Development [ON173035, ON175038]
Astrocytes are the most abundant cell population within the CNS of mammals. Their glial role is perfectly performed in the healthy CNS as they support functions of neurons. The omnipresence of astrocytes throughout the white and grey matter and their intimate relation with blood vessels of the CNS, as well as numerous immunity-related actions that these cells are capable of, imply that astrocytes should have a prominent role in neuroinflammatory disorders, such as multiple sclerosis (MS). The role of astrocytes in MS is rather ambiguous, as they have the capacity to both stimulate and restrain neuroinflammation and tissue destruction. In this paper we present some of the proved and the proposed functions of astrocytes in neuroinflammation and discuss the effect of MS therapeutics on astrocytes. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据