期刊
FEBS LETTERS
卷 585, 期 3, 页码 539-544出版社
WILEY
DOI: 10.1016/j.febslet.2010.12.044
关键词
Thyroid hormone; Deiodinase; Chemical chaperone; Oxygen consumption; Metabolism
资金
- NIDDK [DK65055]
Exposure of cell lines endogenously expressing the thyroid hormone activating enzyme type 2 deiodinase (D2) to the chemical chaperones tauroursodeoxycholic acid (TUDCA) or 4-phenylbutiric acid (4-PBA) increases D2 expression, activity and T3 production. In brown adipocytes, TUDCA or 4-PBA induced T3-dependent genes and oxygen consumption (similar to 2-fold), an effect partially lost in D2 knockout cells. In wild type, but not in D2 knockout mice, administration of TUDCA lowered the respiratory quotient, doubled brown adipose tissue D2 activity and normalized the glucose intolerance associated with high fat feeding. Thus, D2 plays a critical role in the metabolic effects of chemical chaperones. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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