期刊
FEBS LETTERS
卷 585, 期 8, 页码 1223-1230出版社
WILEY
DOI: 10.1016/j.febslet.2011.03.042
关键词
Cellular AMP level; Mitochondrial oxidation; Glucose homeostasis; Glycogen storage
资金
- National Institute of Health [DK080339]
- American Heart Association [0665535Y]
- ARCS Foundation
- Rees-Stealy Research Foundation
Thioredoxin-interacting protein (Txnip) knockout (TKO) mice exhibit impaired response to fasting. Herein, we showed that activation of adenine monophosphate-activated protein kinase and cellular AMP levels were diminished in the heart and soleus muscle but not in gastrocnemius muscle of fasting TKO mice. Similarly, glycogen content in fasted TKO mice was increased in oxidative muscles but was not different in glycolytic muscles. These data suggest Txnip deficiency has a higher impact on oxidative muscle than glycolytic muscles and provide new insights into the metabolic role of Txnip. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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