期刊
FEBS LETTERS
卷 585, 期 14, 页码 2285-2290出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2011.05.057
关键词
Obesity; Inflammation; Adipose tissue; Insulin resistance
资金
- Ministry of Education, Science and Technology [KRF-2007-313-F00148, 2010-0001886]
- Ministry of Education, Culture, Sport, Science and Technology of Japan [22228001]
- Korean Government (MOEHRD) [BRL-2010-0087350]
HVEM is a member of the TNF receptor superfamily that plays a role in the development of various inflammatory diseases. In this study, we show that HVEM deficiency attenuates adipose tissue inflammatory responses and glucose intolerance in diet-induced obesity. Feeding a high-fat diet (HFD) to HVEM-deficient mice elicited a reduction in the number of macrophages and T cells infiltrated into adipose tissue. Proinflammatory cytokine levels in the adipose tissue decreased in HFD-fed HVEM-deficient mice, while levels of the anti-inflammatory cytokine IL-10 increased. Moreover, glucose intolerance and insulin sensitivity were markedly improved in the HFD-fed HVEM-deficient mice. These findings indicate that HVEM may be a useful target for combating obesity-induced inflammatory responses and insulin resistance. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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