期刊
FEBS LETTERS
卷 585, 期 12, 页码 1864-1872出版社
WILEY
DOI: 10.1016/j.febslet.2011.04.052
关键词
Homeobox; Adhesion molecule; Cytokinesis; Development
资金
- Korean Government [KRF-2007-341-C00261]
- BK21 project
We investigated the function of homeodomain-containing protein Hbx4 in Dictyostelium discoideum. Hbx4-overexpressing cells (Hbx4(OE)) displayed defects in growth rate and cytokinesis and showed differences in slug motility and cell-type proportioning from KAx3. Furthermore, the overexpression of Hbx4 inhibited the induction of cadA, which encoded the Ca2+-dependent cell adhesion molecule DdCAD-1, despite expression of csaA and gpaB. The electrophoretic mobility shift assay showed that the promoter of cadA contained the Hbx4-binding site. Moreover, constitutively expressed DdCAD-1 in Hbx4(OE) rescued the defects in cytokinesis and development. These results suggest that Hbx4 modulates DdCAD-1-mediated cytokinesis and cell-type proportioning. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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