期刊
FEBS LETTERS
卷 584, 期 8, 页码 1571-1576出版社
WILEY
DOI: 10.1016/j.febslet.2010.03.012
关键词
alpha-Synuclein; Dopamine; Parkinson's disease; Mitochondria; Membrane potential; Phosphorylation
资金
- Life Sciences Research Board, Defence Research and Development Organization, Government of India [LSRB-93/EPB/2006]
- National Health and Medical Research Council (NHMRC) of Australia
- Indian Council of Medical Research, New Delhi
This study demonstrates that in vitro incubation of isolated rat brain mitochondria with recombinant human alpha-synuclein leads to dose-dependent loss of mitochondrial transmembrane potential and phosphorylation capacity. However, alpha-synuclein does not seem to have any significant effect on the activities of respiratory chain complexes under similar conditions of incubation suggesting that the former may impair mitochondrial bioenergetics by direct effect on mitochondrial membranes. Moreover, the recombinant wild type alpha-synuclein and different mutant forms (A30P, A53T and E46K) have essentially similar effects on rat brain isolated mitochondria. The results are significant in view of the fact that alpha-synucleinopathy is involved in the pathogenesis of Parkinson's disease. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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