期刊
FEBS LETTERS
卷 584, 期 14, 页码 3193-3197出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2010.06.006
关键词
Neutrophil; Neutrophil extracellular trap; Endothelial cell
资金
- Swiss National Science Foundation [310000-118468/1]
- Herzkreislauf Stiftung
- EU
Neutrophil interaction with activated endothelial cells (EC) is required for transmigration. We examined consequences of this interaction on NETosis. Co-culture of activated EC with neutrophils induced neutrophil extracellular trap (NET) formation, which was partially dependent on production of IL-8 by activated EC. Extended neutophil/EC co-culture resulted in EC damage, which could be abrogated by inclusion of either diphenyleneiodonium to inhibit the NAPDH oxidase pathway required for NETosis, or DNAse to disrupt NETs. These findings offer new insight into mechanisms whereby NETs trigger damage to the endothelium in sepsis, small vessel vasculitis and possibly the villous trophoblast in preeclampsia. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据