期刊
FEBS LETTERS
卷 584, 期 13, 页码 2786-2790出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2010.05.006
关键词
Respiratory syncytial virus; Viroporin; Channel; SH protein
资金
- Wellcome Trust
- BBSRC/Pfizer
- University of Leeds Biomedical Health Research Centre
Human respiratory syncytial virus (HRSV) is the leading cause of lower respiratory tract disease in infants. The HRSV small hydrophobic (SH) protein plays an important role in HRSV pathogenesis, although its mode of action is unclear. Analysis of the ability of SH protein to induce membrane permeability and form homo-oligomers suggests it acts as a viroporin. For the first time, we directly observed functional SH protein using electron microscopy, which revealed SH forms multimeric ring-like objects with a prominent central stained region. Based on current and existing functional data, we propose this region represents the channel that mediates membrane permeability.
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