期刊
FEBS LETTERS
卷 584, 期 17, 页码 3717-3724出版社
WILEY
DOI: 10.1016/j.febslet.2010.05.021
关键词
H2AX; MRE11/RAD50/NBS1; DNA damage; DNA repair; Non-homologous end-joining; Homologous recombination
资金
- National Institutes of Health [CA089239, CA092312, CA100109]
- Department of Defense [W81XWH-05-1-0470]
- M.D. Anderson Cancer Center [CA016672]
Phosphorylation of histone variant H2AX at serine 139, named gamma H2AX, has been widely used as a sensitive marker for DNA double-strand breaks (DSBs). gamma H2AX is required for the accumulation of many DNA damage response (DDR) proteins at DSBs. Thus it is believed to be the principal signaling protein involved in DDR and to play an important role in DNA repair. However, only mild defects in DNA damage signaling and DNA repair were observed in H2AX-deficient cells and animals. Such findings prompted us and others to explore H2AX-independent mechanisms in DNA damage response. Here, we will review recent advances in our understanding of H2AX-dependent and independent DNA damage signaling and repair pathways in mammalian cells. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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