期刊
FEBS LETTERS
卷 584, 期 7, 页码 1386-1392出版社
WILEY
DOI: 10.1016/j.febslet.2010.02.060
关键词
Parkin; Parkinson's disease; Mitophagy; Mitochondrial quality control; PINK1
资金
- NINDS/NIH
- JSPS
Cellular homeostasis is linked tightly to mitochondrial functions. Some damage to mitochondrial proteins and nucleic acids can lead to the depolarization of the inner mitochondrial membrane, thereby sensitizing impaired mitochondria for selective elimination by autophagy. Mitochondrial dysfunction is one of the key aspects of the pathobiology of neurodegenerative disease. Parkin, an E3 ligase located in the cytosol and originally discovered as mutated in monogenic forms of Parkinson's disease (PD), was found recently to translocate specifically to uncoupled mitochondria and to induce their autophagy. Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.
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