期刊
FEBS LETTERS
卷 584, 期 11, 页码 2445-2454出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2010.04.050
关键词
Infection; Endoplasmic reticulum stress
资金
- Chungnam National University
- National Research Foundation of Korea (NRF)
- Ministry of Education, Science and Technology [2010-0001284]
Mycobacterium tuberculosis (Mtb) infection leads to the induction of the apoptotic response, which is associated with bacilli killing. The early secreted mycobacterial antigen ESAT-6 of Mtb has been shown to induce apoptosis in human macrophages and epithelial cells. In the present study, we demonstrate that the stimulation of human epithelial A549 cells by ESAT-6 induces the endoplasmic reticulum (ER) stress response. We observed that ESAT-6 treatment increases intracellular Ca(2+) concentration, which results in ROS accumulation, and therefore induces the onset of ER stress-induced apoptosis. Our results uncover a novel apoptotic mechanism of ESAT-6 through ER stress responses in pathologic conditions such as tuberculosis. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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