期刊
FEBS LETTERS
卷 584, 期 10, 页码 1942-1947出版社
WILEY
DOI: 10.1016/j.febslet.2010.01.010
关键词
Calcium signaling; ER Ca2+ release; grp75; IP3 receptor; Letm1; mCa1; mCa2; MiCa; MCU; Mitochondrial Ca2+ uniporter; Mitofusin; p38MAPK; Uncoupling protein; UCP2/3
资金
- Austrian Science Funds (FWF) [P20181-B05, 21857-B18, F3010-B05]
- Austrian Science Fund (FWF) [P20181] Funding Source: Austrian Science Fund (FWF)
- Austrian Science Fund (FWF) [P 21857] Funding Source: researchfish
Mitochondria process local and global Ca2+ signals. Thereby the spatiotemporal patterns of mitochondrial Ca2+ signals determine whether the metabolism of these organelles is adjusted or cell death is executed. Mitochondrial Ca2+ channels of the inner mitochondrial membrane ( IMM) actually implement mitochondrial uptake from cytosolic Ca2+ rises. Despite great efforts in the past, the identity of mitochondrial Ca2+ channels is still elusive. Numerous studies aimed to characterize mitochondrial Ca2+ uniport channels and provided a detailed pro. le of these great unknowns with important functions. This mini-review revisits previous research on the mechanisms of mitochondrial Ca2+ uptake and aligns them with most recent findings. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据