期刊
FEBS LETTERS
卷 584, 期 7, 页码 1405-1410出版社
WILEY
DOI: 10.1016/j.febslet.2010.01.008
关键词
Antigen presentation; T cell selection; Innate immunity; Macroautophagy; Intracellular pathogen; Vaccination
资金
- Deutsche Forschungsgemeinschaft [SFB455, SFB571, KL1228/2-1, KL1228/3-1]
- Hertie-Foundation
- National Cancer Institute [R01CA108609, R01CA101741]
- Swiss National Science Foundation [310030_126995]
- Foundation for the National Institutes of Health
Macroautophagy, a homeostatic process that shuttles cytoplasmic constituents into endosomal and lysosomal compartments, has recently been shown to deliver antigens for presentation on major histocompatibility complex (MHC) class II. Autophagy-mediated antigen processing in thymic epithelial cells has been suggested to be involved in the generation of a self-MHC restricted and self-tolerant CD4(+) T cell repertoire. Furthermore, there is accumulating evidence that the up-regulation of autophagy by pattern-recognition receptor signaling represents an innate defense mechanism against intracellular pathogens. Thus, through linking pathogen breakdown with the presentation of pathogen-derived autophagy substrates on MHC class II, autophagy serves a dual function at the interface of the innate and the adaptive immune response. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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