期刊
FEBS LETTERS
卷 584, 期 7, 页码 1342-1349出版社
WILEY
DOI: 10.1016/j.febslet.2010.01.006
关键词
Autophagy-related gene 1; Unc-51 like kinase 1; Vps34; Jun-N-terminal kinase; Target of rapamycin
资金
- NIGMS NIH HHS [R01 GM062509-09, R01 GM062509] Funding Source: Medline
Drosophila has been shown to be a powerful model to study autophagy, whose regulation involves a core machinery consisting of Atg proteins and upstream signaling regulators similar to those in yeast and mammals. The conserved role in degrading proteins and organelles gives autophagy an important function in coordinating several cellular processes as well as in a number of pathological conditions. This review summarizes key studies in Drosophila autophagy research and discusses potential questions that may lead to better understanding of the roles and regulation of autophagy in higher eukaryotes. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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