期刊
FEBS LETTERS
卷 584, 期 24, 页码 4901-4909出版社
WILEY
DOI: 10.1016/j.febslet.2010.10.025
关键词
Signal transduction; Immunoreceptor; Adapter protein; SLP-76
资金
- NCI NIH HHS [P01 CA093615-10, P01 CA093615] Funding Source: Medline
- NIGMS NIH HHS [R37 GM053256-17, R37 GM053256] Funding Source: Medline
Immunoreceptor engagement leads to the activation of multiple second messenger cascades, and integration of these pathways requires proper function of a number of adapter proteins. Although adapters possess no intrinsic enzymatic function, they nucleate the formation of multi-molecular protein complexes to support downstream signaling. Since adapters contain functionally distinct domains, intense investigation has been devoted to understanding how these regions act to integrate signals. This review describes the evolution of studies investigating one of these adapters, the SH2 domain-containing leukocyte protein of 76 kDa. Through utilizing biochemical, genetic and imaging techniques, a model has emerged describing how this adapter regulates signals resulting in complex immune responses. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据