期刊
FEBS LETTERS
卷 584, 期 24, 页码 4910-4914出版社
WILEY
DOI: 10.1016/j.febslet.2010.09.042
关键词
Ikaros; Transcription factors; B-Cell development; Pre-B cell receptor; Cell cycle progression
资金
- Leukaemia and Lymphoma Research (LLR)
- Medical Research Council, UK
- Medical Research Council [MC_U120027516] Funding Source: researchfish
- MRC [MC_U120027516] Funding Source: UKRI
Ikaros is the founding member of a family of transcription factors. Ikaros proteins are required for the normal development of lymphocytes and other blood cell lineages, and have an important role in haematopoietic malignancies. Accumulating data link Ikaros to immune receptor rearrangement and signaling, and the balance between proliferation and differentiation of immune cells. The emerging picture is that Ikaros family members are critical for a functional immune system that confers protection against invading pathogens, while minimising the risk of leukaemic transformation, immune pathology, and autoimmunity. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据