期刊
FEBS LETTERS
卷 584, 期 12, 页码 2572-2579出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2010.04.057
关键词
Antibody; B cell; Pre-B cell receptor checkpoint; Positive selection; Negative selection
资金
- Swedish Cancer Foundation
- Swedish Research Council
- Torsten and Ragnar Soderbergs Stiftelser
- Sahlgrenska Academy
- ALF fund
B lymphocytes are essential antibody-producing cells of the immune system. During the development of progenitor B cells to mature B cells that express a membrane-bound antibody, the B cell receptor (BCR), the cells undergo selection at several checkpoints, which ensures that a diverse antibody repertoire is generated and that the BCRs recognise foreign-, but not self-, antigens. In this review, we consider the pre-BCR checkpoint. Mutations or alterations that affect this checkpoint underpin the development of pre-B cell leukemias, primary immunodeficiency, and possibly, systemic autoimmunity. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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