期刊
FEBS LETTERS
卷 584, 期 11, 页码 2485-2490出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2010.04.067
关键词
Hepatitis B virus; Metabolovirus; Anti-viral therapy; Nutrition
资金
- Sackler faculty of Medicine, Tel-Aviv University
- United States-Israel Binational Science Foundation (BSF) [2007285]
Hepatitis B virus (HBV) infects the liver and uses its cell host for gene expression and propagation. Therefore, targeting host factors essential for HBV gene expression is a potential anti-viral strategy. Here we show that treating HBV expressing cells with the natural phenolic compound curcumin inhibits HBV gene expression and replication. This inhibition is mediated via down-regulation of PGC-1 alpha, a starvation-induced protein that initiates the gluconeogenesis cascade and that has been shown to robustly coactivate HBV transcription. We suggest curcumin as a host targeted therapy for HBV infection that may complement current virus-specific therapies. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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