期刊
FEBS LETTERS
卷 584, 期 8, 页码 1615-1622出版社
WILEY
DOI: 10.1016/j.febslet.2010.03.025
关键词
ALS; Astrocyte; SOD1; Heme oxygenase-1; Transgenic mice
资金
- Natural Science Foundation of China [30670732, 30870882, 30900460]
- Science and Technological department of Hebei Province [08966105D]
The SOD1-G93A transgenic mouse is a widely used ALS model, but the death of lower motor neurons is the hallmark. Here, we show that the SOD1-G93A transgene and HO-1 are preferentially over-expressed in the lumbar spinal cord, particularly in the activated astrocytes of the transgenic mice. We also show down-regulation of GLT-1 in spite of the proliferating astrocytes. However, GLT-1, SOD1-G93A transgene and HO-1 expression were not obviously changed in the motor cortex. Our data link spinal cord vulnerability to relatively decreased expression of GLT-1, and high expression of the transgene and HO-1 in astrocytes in SOD1-G93A transgenic mice. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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