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Graham P. Cook et al.
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AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA
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AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC
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An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome
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Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization
Veit Hornung et al.
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Critical role for Cryopyrin/Nalp3 in activation of caspase-1 in response to viral infection and double-stranded RNA
Thirumala-Devi Kanneganti et al.
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Double-stranded RNA is produced by positive-strand RNA viruses and DNA viruses but not in detectable amounts by negative-strand RNA viruses
Friedemann Weber et al.
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Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3
TD Kanneganti et al.
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