期刊
FEBS LETTERS
卷 584, 期 11, 页码 2427-2432出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2010.04.048
关键词
Reactive oxygen species; Catalase; Promoter methylation; Hepatocellular carcinoma
资金
- Ministry of Health and Welfare, Korea [0820150]
- Ministry of Education and Human Resources Development
- Korea Health Promotion Institute [0820150] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Catalase, which decomposes reactive oxygen species (ROS), is reduced in hepatocellular carcinoma (HCC); however, the reasons are poorly defined. In this study, it is demonstrated that prolonged exposure to ROS induced methylation of CpG island II on the catalase promoter and downregulated catalase expression at the transcriptional level in HCC cell lines. In addition, hypermethylation of CpG island II was also observed in tumor tissues, together with a decrease in catalase mRNA and protein expression levels when compared to non-tumor tissues. From these data, we suggest that ROS may downregulate catalase through the methylation of promoter during the development of HCC. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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