期刊
FEBS LETTERS
卷 584, 期 4, 页码 837-842出版社
WILEY
DOI: 10.1016/j.febslet.2010.01.015
关键词
Hepatitis C virus; Porcine teschovirus; 3 '-untranslated region; Poly(A); Picornavirus; Internal ribosome entry site
资金
- Deutsche Forschungsgemeinschaft (DFG,) [IRTG 1384]
- Russian Foundation for Basic Research (RFBR)
- Universit tsklinikum Giessen und Marburg GmbH (KOOPV)
Translation of hepatitis C virus (HCV) genomic RNA is directed by an internal ribosome entry site (IRES) in the 5'-untranslated region (5'-UTR), and the HCV 3'-UTR enhances IRES activity. Since the HCV 3'-UTR has a unique structure among 3'-UTRs, we checked possible communication between the 5'- and the 3'-UTR of HCV during translation using chimeric reporter RNAs. We show that translation directed by the HCV IRES and by the HCV-like IRES of porcine teschovirus (PTV) which belongs to a quite distinct family of viruses (picornaviruses) or by the EMCV IRES is also enhanced by the HCV 3'-UTR or by a poly(A)-tail in different cell types. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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