期刊
FEBS LETTERS
卷 584, 期 14, 页码 3123-3130出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2010.05.052
关键词
Retinoid signaling; Retinoic acid receptor; All-trans retinoic acid; Mouse embryonic stem cell; Embryoid body; Transcription
资金
- Wellcome Trust
- Hungarian Scientific Research Fund [OTKA NK72730, OTKA F68254]
- Richter Gedeon PhD Fellowship
- Hungarian Academy of Sciences
- [TAMOP-4.2.2/08/1]
Retinoid signaling has been implicated in embryonic stem cell differentiation. Here we present a systematic analysis of gene expression changes in mouse embryonic stem cells (mESCs), during their spontaneous differentiation into embryoid bodies and the effect of all-trans retinoic acid (ATRA) on this process. We show that retinoic acid is present in the serum and is sufficient to activate retinoid signaling at a basal level in undifferentiated mESCs. This signal disappears during embryoid body formation. However exogenously added ATRA resets the spontaneous differentiation programs in embryoid bodies and initiates a distinct genetic program. These data suggest that retinoid signaling not only promotes a particular pathway but also acts as a context dependent general coordinator of the differentiation states in embryonic stem cells. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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