期刊
FEBS LETTERS
卷 584, 期 10, 页码 1997-2004出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2010.01.012
关键词
Patch-clamp; Permeability transition pore; Mitochondrial megachannel; Electrophysiology; Mitochondrial protein import; Tim23
资金
- Italian Foundation for Cancer Research [AIRC 5118]
- Fondazione Cassa di Risparmio di Padova e Rovigo (CARI-PARO)
- University of Padova
- Associazione Italiana per la Ricerca sul Cancro Funding Source: Custom
After a brief review of the early history of mitochondrial electrophysiology, the contribution of this approach to the study of the mitochondrial permeability transition (MPT) is recapitulated. It has for example provided evidence for a dimeric nature of the MPT pore, allowed the distinction between two levels of control of its activity, and underscored the relevance of redox events for the phenomenon. Single-channel recording provides a means to finally solve the riddle of the biochemical entity underlying it by comparing the characteristics of the pore with those of channels formed by candidate molecules or complexes. The possibility that this entity may be the protein import machinery of the inner mitochondrial membrane is emphasized. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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