期刊
FEBS LETTERS
卷 585, 期 7, 页码 944-951出版社
WILEY
DOI: 10.1016/j.febslet.2010.12.034
关键词
LKB1; Lung adenocarcinoma; Cervical cancer; Peutz-Jeghers syndrome; AMPK; p53
资金
- European ENFIN grant [LSHG-CT-2005-518254]
- Sigrid Juselius Foundation
- Academy of Finland
- Finnish Cancer Foundation
The LKB1 tumor suppressor gene is frequently mutated in sporadic lung adenocarcinomas and cervical cancers and germline mutations are causative for Peutz-Jeghers syndrome characterized by gastrointestinal polyposis. The intracellular LKB1 kinase is implicated in regulating polarity, metabolism, cell differentiation, and proliferation - all functions potentially contributing to tumor suppression. LKB1 acts as an activating kinase of at least 14 kinases mediating LKB1 functions in a complex signaling network with partial overlaps. Regulation of the LKB1 signaling network is highly context dependent, and spatially organized in various cellular compartments. Also the mechanisms by which LKB1 activity suppresses tumorigenesis is context dependent, where recent observations are providing hints on the molecular mechanisms involved. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据