期刊
FEBS LETTERS
卷 584, 期 16, 页码 3587-3591出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2010.07.026
关键词
Apigenin; Flavone; DAF-16; DAF-2; Growth inhibition; Caenorhabditis elegans
资金
- Ministry of Education, Science and Technology, Korea [KRF 2006-005-J03401, NRF 2009-0093824, NRF 20100009509]
Treatment of Caenorhabditis elegans with apigenin, 5,7,4 '-trihydroxyflavone, induces larval growth inhibition. To understand the molecular basis of apigenin-induced larval growth inhibition, the effects of apigenin on DAF-16 activity were examined. DAF-16 was activated through nuclear translocation and the mRNA level of sod-3, one of the known DAF-16 target genes, was increased upon apigenin treatment. DAF-16 activity was required for the growth inhibition, since the larval growth retardation upon apigenin treatment was suppressed in daf-16 mutants. These results indicate that apigenin acts as a stressor that activates DAF-16, which in turn inhibits larval growth. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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