期刊
FEBS LETTERS
卷 584, 期 8, 页码 1515-1520出版社
WILEY
DOI: 10.1016/j.febslet.2010.02.071
关键词
Janus kinase; Apoptosis; Lymphoid cancer; Microarray; Gene expression
资金
- Texas Ignition Fund
- Lizanell and Colbert Coldwell Foundation
- ZSN [S06 GM008012-37]
- National Center for Research Resources (NCRR) [5G12RR008124]
In the current work, we report that specific inhibition of Janus tyrosine kinase (JAK3) via NC1153 induces apoptosis of certain leukemia/lymphoma cell lines. Affymetrix microarray profiling following NC1153 treatment unveiled JAK3 dependent survival modulating pathways (p53, TGF-beta, TNFR and ER stress) in Kit225 cells. IL-2 responsive NC1153 target genes were regulated in human JAK3 positive, but not in JAK3 negative lymphoid tumor cells. Moreover, primary lymphoma samples revealed that a number of these genes were reciprocally regulated during disease progression and JAK3 inhibition suggesting that downstream targets of JAK3 could be exploited in the development of novel cancer treatment regimes. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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