期刊
FEBS LETTERS
卷 584, 期 9, 页码 1814-1823出版社
WILEY
DOI: 10.1016/j.febslet.2010.02.047
关键词
Plasma membrane; Single-molecule tracking; Fluorescence correlation spectroscopy; Raft domains; Compartmentalization; Actin filament
资金
- Grants-in-Aid for Scientific Research [21570167] Funding Source: KAKEN
Single-molecule tracking and fluorescence correlation spectroscopy (FCS) applied to the plasma membrane in living cells have allowed a number of unprecedented observations, thus fostering a new basic understanding of molecular diffusion, interaction, and signal transduction in the plasma membrane. It is becoming clear that the plasma membrane is a heterogeneous entity, containing diverse structures on nano-meso-scales (2-200 nm) with a variety of lifetimes, where certain membrane molecules stay together for limited durations. Molecular interactions occur in the time-dependent inhomogeneous two-dimensional liquid of the plasma membrane, which might be a key for plasma membrane functions. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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