期刊
FEBS LETTERS
卷 584, 期 8, 页码 1503-1508出版社
WILEY
DOI: 10.1016/j.febslet.2010.02.069
关键词
Ghrelin; AMP-activated protein kinase; Uncoupling protein 2; Insulin secretion
Ghrelin inhibits insulin secretion partly via induction of IA-2b. However, the orexigenic effect of ghrelin is mediated by the AMP-activated protein kinase (AMPK)-uncoupling protein 2 (UCP2) pathway. Here, we demonstrate that ghrelin's inhibitory effect on insulin secretion also occurs through the AMPK-UCP2 pathway. Ghrelin increased AMPK phosphorylation and UCP2 mRNA expression in MIN6 insulinoma cells. Overexpression or downregulation of UCP2 attenuated or enhanced insulin secretion, respectively. Furthermore, AMPK activator had a similar effect to ghrelin on UCP2 and insulin secretion in MIN6 cells. In conclusion, ghrelin's inhibitory effect on insulin secretion is partly mediated by the AMPK-UCP2 pathway, which is independent of the IA-2b pathway. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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