期刊
FEBS LETTERS
卷 584, 期 3, 页码 599-604出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2009.12.008
关键词
Dipeptide; Tyr-Leu; Anxiolytic-like activity; Serotonin 5-HT1A receptor; Dopamine D-1 receptor; GABA(A) receptor; Monoamine
资金
- Japanese Society for the Promotion of Science
- Japan Dairy Association
We found that Tyr-Leu (YL) dose-dependently exhibits potent anxiolytic-like activity (0.1-1 mg/kg, i.p.) comparable to diazepam in the elevated plus-maze test in mice. YL was orally active (0.33 mg/kg). A retro-sequence peptide or a mixture of Tyr and Leu was inactive. The anxiolytic-like activity of YL was inhibited by antagonists for serotonin 5-HT1A, dopamine D-1 and GABA(A) receptors; however, YL had no affinity for them. We also determined the order of their activation is 5-HT1A, D-1 and GABAA receptors using selective agonists and antagonists. Taken together, YL may exhibit anxiolytic-like activity via activation of 5-HT1A, D-1 and GABA(A) receptors. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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