期刊
FEBS LETTERS
卷 584, 期 4, 页码 701-706出版社
WILEY
DOI: 10.1016/j.febslet.2009.12.018
关键词
Proprotein convertase; Pancreatic islet beta cell; Cholesterol, low-density lipoprotein; Glucose
资金
- Canadian Institute of Health Research
- Canadian Diabetes Association
- Heart and Stroke Foundation of Canada
- Strauss Foundation
Proprotein convertase subtilisin/kexin type 9 (PCSK9), a liver-secreted plasma enzyme, restricts hepatic uptake of low-density lipoprotein (LDL) cholesterol by promoting the degradation of LDL receptors (LDLR). PCSK9 and LDLR are also expressed in insulin-producing pancreatic islet beta cells, possibly affecting the function of these cells. Here we show that, compared to control mice, PCSK9-null male mice over 4 months of age carried more LDLR and less insulin in their pancreas; they were hypoinsulinemic, hyperglycemic and glucose-intolerant; their islets exhibited signs of malformation, apoptosis and inflammation. Collectively, these observations suggest that PCSK9 may be necessary for the normal function of pancreatic islets. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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