期刊
FEBS LETTERS
卷 583, 期 23, 页码 3863-3871出版社
WILEY
DOI: 10.1016/j.febslet.2009.10.053
关键词
Endoplasmic reticulum; Chaperone; Src family kinase; Golgi complex; Cell signalling
资金
- AIRC (Italy)
- FIRC Fellowship
The KDEL receptor is a seven-transmembrane-domain protein that was first described about 20 years ago. Its well-known function is to retrotransport chaperones from the Golgi complex to the endoplasmic reticulum. Recent studies, however, have suggested that the KDEL receptor has additional functions. Indeed, we have demonstrated that chaperone-bound KDEL receptor triggers the activation of Src family kinases on the Golgi complex. This activity is essential in the regulation of Golgi-to-plasma membrane transport. However, the identification of different KDEL receptor interactors that are inconsistent with these established functions opens the possibility of further receptor activities. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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