期刊
FEBS LETTERS
卷 584, 期 9, 页码 1760-1770出版社
WILEY
DOI: 10.1016/j.febslet.2009.10.085
关键词
Myelin; Trafficking; Microdomain; Proteolipid protein; Myelin basic protein; Sorting
资金
- Dutch MS Research Foundation
- Netherlands Organization of Scientific Research (NWO)
In the central nervous system, a multilayered membrane layer known as the myelin sheath enwraps axons, and is required for optimal saltatory signal conductance. The sheath develops from membrane processes that extend from the plasma membrane of oligodendrocytes and displays a unique lipid and protein composition. Myelin biogenesis is carefully regulated, and multiple transport pathways involving a variety of endosomal compartments are involved. Here we briefly summarize how the major myelin proteins proteolipid protein and myelin basic protein reach the sheath, and highlight potential mechanisms involved, including the role of myelin specific lipids and cell polarity related transport pathways. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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