期刊
FEBS LETTERS
卷 583, 期 24, 页码 3959-3965出版社
WILEY
DOI: 10.1016/j.febslet.2009.11.032
关键词
Fungal; Regulatory; Evolution; Expression; Divergence
资金
- Howard Hughes Medical Institute Funding Source: Medline
- NIH HHS [DP1 OD003958] Funding Source: Medline
Regulatory divergence is likely a major driving force in evolution. Comparative genomics is being increasingly used to infer the evolution of gene regulation. Ascomycota fungi are uniquely suited among eukaryotes for regulatory evolution studies, due to broad phylogenetic scope, many sequenced genomes, and tractability of genomic analysis. Here we review recent advances in the identification of the contribution of cis- and trans-factors to expression divergence. Whereas current strategies have led to the discovery of surprising signatures and mechanisms, we still understand very little about the adaptive role of regulatory evolution. Empirical studies including experimental evolution, comparative functional genomics and hybrid and engineered strains are showing early promise toward deciphering the contribution of regulatory divergence to adaptation. (c) 2009 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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