期刊
FEBS LETTERS
卷 583, 期 23, 页码 3804-3810出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2009.10.084
关键词
Polarized trafficking; Centrosome; Intermediate compartment; Endosome; Golgi bypass pathway
资金
- Research Council of Norway
The intermediate compartment (IC) between the endoplasmic reticulum (ER) and the Golgi apparatus appears to constitute an autonomous organelle composed of spatially and functionally distinct, but interconnected, vacuolar and tubular subdomains. In mammalian cells the IC network is stably anchored at the cell center, communicating directly with the endocytic pathway via a pericentrosomal membrane system (PCMS). This finding suggests that the secretory pathway divides at the level of the IC, which functions as a sorting station both in Golgi-dependent and -independent trafficking. The tubular subdomain of the IC is capable of expansion in accordance with its proposed biosynthetic functions such as cholesterol synthesis. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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