期刊
FEBS LETTERS
卷 584, 期 10, 页码 2161-2166出版社
WILEY
DOI: 10.1016/j.febslet.2009.12.033
关键词
Mitochondrial ion channel; ATP-sensitive potassium channel; Calcium-activated potassium channel; Permeability transition pore; Calcium uniporter; Cardioprotection
资金
- Ministry of Education, Culture, Sports, Science and Technology of Japan
Over the past decades there has been considerable progress in understanding the multifunctional roles of mitochondrial ion channels in metabolism, energy transduction, ion transport, signaling, and cell death. Recent data have suggested that some of these channels function under physiological condition, and others may be activated in response to pathological insults and play a key role in cytoprotection. This review outlines our current understanding of the molecular identity and pathophysiological roles of the mitochondrial ion channels in the heart with particular emphasis on cardioprotection against ischemia/reperfusion injury, and future research on mitochondrial ion channels. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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