期刊
FEBS LETTERS
卷 584, 期 2, 页码 359-365出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2009.11.038
关键词
tRNA packaging; HIV-1 assembly; Capsid; Gag; Gag-Pol; Lysyl-tRNA synthetase
资金
- NIAID NIH HHS [R01 AI077387-01A2, R01 AI054145-04] Funding Source: Medline
Human immunodeficiency virus 1 (HIV-1) uses a host cell tRNALys, 3 molecule to prime reverse transcription of the viral RNA genome into double-stranded DNA prior to integration into the host genome. All three human tRNALys isoacceptors along with human lysyl-tRNA synthetase (LysRS) are selectively packaged into HIV-1. Packaging of LysRS requires the viral Gag polyprotein and incorporation of tRNALys additionally requires the Gag-Pol precursor. A model that incorporates the known interactions between components of the putative packaging complex is presented. The molecular interactions that direct assembly of the tRNALys/LysRS packaging complex hold promise for the development of new anti-viral agents. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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