期刊
FEBS LETTERS
卷 583, 期 23, 页码 3839-3846出版社
WILEY
DOI: 10.1016/j.febslet.2009.11.012
关键词
Membrane fission; Dynamin; Dynamin-like protein; ESCRT-III; Membrane tension; Lipid phase separation; Caveolae; COP; Organelle division
Membrane fission is the last step of membrane carrier formation. As fusion, it is a very common process in eukaryotic cells, and participates in the integrity and specificity of organelles. Although many proteins have been isolated to participate in the various membrane fission reactions, we are far from understanding how membrane fission is mechanically triggered. Here we aim at reviewing the well-described examples of dynamin and lipid phase separation, and try to extract the essential requirements for fission. Then, we survey the recent knowledge obtained on other fission reactions, analyzing the similarities and differences with previous examples. (C) 2009 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.
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