期刊
FEBS LETTERS
卷 583, 期 24, 页码 3979-3983出版社
WILEY
DOI: 10.1016/j.febslet.2009.11.035
关键词
Single molecule; Transcription factor; Facilitated diffusion
Quantitative modeling of intracellular processes often requires information about intracellular rate constants as well as the concentrations of low abundance species in individual cells. Single molecule imaging techniques offer not only new ways for obtaining such information but also the possibilities to test model-based hypotheses that have previously been out of reach for experiments. In this review we highlight some advantages of single molecule techniques and exemplify by their capability to help understanding how transcription factors find their chromosomal binding sites in bacterial cells. (c) 2009 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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